Atacand (candesartan) dosing, indications, interactions, adverse effects, and more (2024)

  • acebutolol

    candesartan and acebutolol both increase serum potassium. Use Caution/Monitor.acebutolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • aceclofenac

    candesartan and aceclofenac both increase serum potassium. Use Caution/Monitor.

  • acemetacin

    candesartan and acemetacin both increase serum potassium. Use Caution/Monitor.

  • albiglutide

    candesartan increases effects of albiglutide by Other (see comment). Use Caution/Monitor. Comment: Angiotensin II receptor antagonists may enhance hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. Monitor patients for changes in glycemic control.

  • aldesleukin

    aldesleukin increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • amifostine

    amifostine, candesartan.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine.

  • amiloride

    candesartan and amiloride both increase serum potassium. Modify Therapy/Monitor Closely.

  • aspirin

    candesartan and aspirin both increase serum potassium. Use Caution/Monitor.aspirin decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, aspirin.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • aspirin rectal

    candesartan and aspirin rectal both increase serum potassium. Use Caution/Monitor.

  • aspirin/citric acid/sodium bicarbonate

    aspirin/citric acid/sodium bicarbonate decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan and aspirin/citric acid/sodium bicarbonate both increase serum potassium. Use Caution/Monitor.candesartan, aspirin/citric acid/sodium bicarbonate.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • atenolol

    candesartan and atenolol both increase serum potassium. Use Caution/Monitor.atenolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • avanafil

    avanafil increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • bendroflumethiazide

    candesartan increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • betaxolol

    candesartan and betaxolol both increase serum potassium. Use Caution/Monitor.betaxolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • bisoprolol

    candesartan and bisoprolol both increase serum potassium. Use Caution/Monitor.bisoprolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • bretylium

    candesartan, bretylium.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Each drug may cause hypotension.

  • brimonidine

    brimonidine increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor.

  • bumetanide

    candesartan increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • canagliflozin

    candesartan and canagliflozin both increase serum potassium. Use Caution/Monitor.

  • carbenoxolone

    candesartan increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • carvedilol

    candesartan and carvedilol both increase serum potassium. Use Caution/Monitor.carvedilol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • celecoxib

    candesartan and celecoxib both increase serum potassium. Use Caution/Monitor.celecoxib decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, celecoxib.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • celiprolol

    candesartan and celiprolol both increase serum potassium. Use Caution/Monitor.celiprolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • chlorothiazide

    candesartan increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • chlorthalidone

    candesartan increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • choline magnesium trisalicylate

    candesartan and choline magnesium trisalicylate both increase serum potassium. Use Caution/Monitor.choline magnesium trisalicylate decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, choline magnesium trisalicylate.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • cyclopenthiazide

    candesartan increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dalteparin

    dalteparin increases toxicity of candesartan by Other (see comment). Use Caution/Monitor. Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion, which can potentially cause hyperkalemia.

  • diclofenac

    candesartan and diclofenac both increase serum potassium. Use Caution/Monitor.diclofenac decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, diclofenac.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • diflunisal

    candesartan and diflunisal both increase serum potassium. Use Caution/Monitor.diflunisal decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, diflunisal.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • digoxin

    candesartan and digoxin both increase serum potassium. Use Caution/Monitor.

  • dopexamine

    candesartan increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • drospirenone

    candesartan and drospirenone both increase serum potassium. Modify Therapy/Monitor Closely.

  • enoxaparin

    enoxaparin increases toxicity of candesartan by Other (see comment). Use Caution/Monitor. Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion, which can potentially cause hyperkalemia.

  • eplerenone

    candesartan, eplerenone. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of hyperkalemia.

  • esmolol

    candesartan and esmolol both increase serum potassium. Use Caution/Monitor.esmolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • ethacrynic acid

    candesartan increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • etodolac

    candesartan and etodolac both increase serum potassium. Use Caution/Monitor.etodolac decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, etodolac.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • exenatide injectable solution

    candesartan increases effects of exenatide injectable solution by Other (see comment). Use Caution/Monitor. Comment: Angiotensin II receptor antagonists may enhance hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. Monitor patients for changes in glycemic control.

  • exenatide injectable suspension

    candesartan increases effects of exenatide injectable suspension by Other (see comment). Use Caution/Monitor. Comment: Angiotensin II receptor antagonists may enhance hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. Monitor patients for changes in glycemic control.

  • fenbufen

    candesartan and fenbufen both increase serum potassium. Use Caution/Monitor.

  • fenoprofen

    candesartan and fenoprofen both increase serum potassium. Use Caution/Monitor.fenoprofen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, fenoprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • flurbiprofen

    candesartan and flurbiprofen both increase serum potassium. Use Caution/Monitor.flurbiprofen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, flurbiprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • furosemide

    candesartan increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • gentamicin

    candesartan increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • heparin

    heparin increases toxicity of candesartan by Other (see comment). Use Caution/Monitor. Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion, which can potentially cause hyperkalemia.

  • hydrochlorothiazide

    candesartan increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ibuprofen

    candesartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • ibuprofen IV

    ibuprofen IV decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan and ibuprofen IV both increase serum potassium. Use Caution/Monitor.candesartan, ibuprofen IV.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • indapamide

    candesartan increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • indomethacin

    candesartan and indomethacin both increase serum potassium. Use Caution/Monitor.indomethacin decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, indomethacin.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • insulin aspart

    candesartan increases effects of insulin aspart by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin aspart protamine/insulin aspart

    candesartan increases effects of insulin aspart protamine/insulin aspart by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin degludec

    candesartan, insulin degludec.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs decrease blood glucose.candesartan increases effects of insulin degludec by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin degludec/insulin aspart

    candesartan, insulin degludec/insulin aspart.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs decrease blood glucose.

  • insulin detemir

    candesartan increases effects of insulin detemir by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin glargine

    candesartan increases effects of insulin glargine by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin glulisine

    candesartan increases effects of insulin glulisine by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin inhaled

    candesartan, insulin inhaled.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs decrease blood glucose.candesartan increases effects of insulin inhaled by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin isophane human/insulin regular human

    candesartan increases effects of insulin isophane human/insulin regular human by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin lispro

    candesartan increases effects of insulin lispro by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin lispro protamine/insulin lispro

    candesartan increases effects of insulin lispro protamine/insulin lispro by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin NPH

    candesartan increases effects of insulin NPH by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • insulin regular human

    candesartan increases effects of insulin regular human by unspecified interaction mechanism. Use Caution/Monitor. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring.

  • ketoprofen

    candesartan and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, ketoprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • ketorolac

    candesartan and ketorolac both increase serum potassium. Use Caution/Monitor.ketorolac decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, ketorolac.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • ketorolac intranasal

    candesartan and ketorolac intranasal both increase serum potassium. Use Caution/Monitor.ketorolac intranasal decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, ketorolac intranasal.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • labetalol

    candesartan and labetalol both increase serum potassium. Use Caution/Monitor.labetalol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • levodopa

    levodopa increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor. Consider decreasing dosage of antihypertensive agent.

  • liraglutide

    candesartan increases effects of liraglutide by Other (see comment). Use Caution/Monitor. Comment: Angiotensin II receptor antagonists may enhance hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. Monitor patients for changes in glycemic control.

  • lornoxicam

    candesartan and lornoxicam both increase serum potassium. Use Caution/Monitor.

  • lurasidone

    lurasidone increases effects of candesartan by Other (see comment). Use Caution/Monitor. Comment: Potential for increased risk of hypotension with concurrent use. Monitor blood pressure and adjust dose of antihypertensive agent as needed.

  • maitake

    maitake increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor.

  • maraviroc

    maraviroc, candesartan.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of orthostatic hypotension.

  • meclofenamate

    meclofenamate decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan and meclofenamate both increase serum potassium. Use Caution/Monitor.candesartan, meclofenamate.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • mefenamic acid

    candesartan and mefenamic acid both increase serum potassium. Use Caution/Monitor.mefenamic acid decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, mefenamic acid.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • meloxicam

    candesartan and meloxicam both increase serum potassium. Use Caution/Monitor.meloxicam decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, meloxicam.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • methyclothiazide

    candesartan increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • methylphenidate

    methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP.

  • methylphenidate transdermal

    methylphenidate transdermal decreases effects of candesartan by anti-hypertensive channel blocking. Use Caution/Monitor.

  • metolazone

    candesartan increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • metoprolol

    candesartan and metoprolol both increase serum potassium. Use Caution/Monitor.metoprolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • nabumetone

    candesartan and nabumetone both increase serum potassium. Use Caution/Monitor.nabumetone decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, nabumetone.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • nadolol

    candesartan and nadolol both increase serum potassium. Use Caution/Monitor.nadolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • naproxen

    candesartan and naproxen both increase serum potassium. Use Caution/Monitor.naproxen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, naproxen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • nebivolol

    candesartan and nebivolol both increase serum potassium. Use Caution/Monitor.nebivolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • nitroglycerin rectal

    nitroglycerin rectal, candesartan.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Observe for possible additive hypotensive effects during concomitant use. .

  • olanzapine/samidorphan

    olanzapine/samidorphan increases effects of candesartan by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Monitor blood pressure and reduce antihypertensive drug dosage in accordance with its product labeling.

  • ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC)

    ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of candesartan by unspecified interaction mechanism. Use Caution/Monitor. Decrease dose of angiotensin receptor blockers and monitor patients for signs and symptoms of hypotension and/or worsening renal function; if such events occur, consider further dose reduction of angiotensin receptor blocker or switching to alternative to angiotensin receptor blocker

  • oxaprozin

    candesartan and oxaprozin both increase serum potassium. Use Caution/Monitor.oxaprozin decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, oxaprozin.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • parecoxib

    candesartan and parecoxib both increase serum potassium. Use Caution/Monitor.

  • penbutolol

    candesartan and penbutolol both increase serum potassium. Use Caution/Monitor.penbutolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • pindolol

    candesartan and pindolol both increase serum potassium. Use Caution/Monitor.pindolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • piroxicam

    candesartan and piroxicam both increase serum potassium. Use Caution/Monitor.piroxicam decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, piroxicam.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • potassium acid phosphate

    candesartan and potassium acid phosphate both increase serum potassium. Use Caution/Monitor.

  • potassium chloride

    candesartan and potassium chloride both increase serum potassium. Use Caution/Monitor.

  • potassium citrate

    candesartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

  • potassium citrate/citric acid

    candesartan and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.

  • potassium iodide

    potassium iodide and candesartan both increase serum potassium. Use Caution/Monitor. Potassium salts may increase the hyperkalemic effects of ARBs; the effect may be the result of aldosterone suppression in patients receiving ARBs.

  • propranolol

    candesartan and propranolol both increase serum potassium. Use Caution/Monitor.propranolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • sacubitril/valsartan

    candesartan and sacubitril/valsartan both increase serum potassium. Use Caution/Monitor.

  • salicylates (non-asa)

    candesartan and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor.

  • salsalate

    candesartan and salsalate both increase serum potassium. Use Caution/Monitor.salsalate decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, salsalate.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • sodium sulfate/?magnesium sulfate/potassium chloride

    sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of candesartan by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

  • sodium sulfate/potassium sulfate/magnesium sulfate

    sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of candesartan by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

  • sotalol

    candesartan and sotalol both increase serum potassium. Use Caution/Monitor.sotalol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • spironolactone

    candesartan and spironolactone both increase serum potassium. Modify Therapy/Monitor Closely.

  • sulfasalazine

    candesartan and sulfasalazine both increase serum potassium. Use Caution/Monitor.sulfasalazine decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, sulfasalazine.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • sulindac

    candesartan and sulindac both increase serum potassium. Use Caution/Monitor.sulindac decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, sulindac.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • synthetic human angiotensin II

    candesartan decreases effects of synthetic human angiotensin II by pharmacodynamic antagonism. Use Caution/Monitor.

  • tadalafil

    tadalafil increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • terbutaline

    candesartan increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • timolol

    candesartan and timolol both increase serum potassium. Use Caution/Monitor.timolol, candesartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy.

  • tizanidine

    tizanidine increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • tolfenamic acid

    candesartan and tolfenamic acid both increase serum potassium. Use Caution/Monitor.

  • tolmetin

    candesartan and tolmetin both increase serum potassium. Use Caution/Monitor.tolmetin decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, tolmetin.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • tolvaptan

    candesartan and tolvaptan both increase serum potassium. Use Caution/Monitor.

  • torsemide

    candesartan increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • treprostinil

    treprostinil increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor.

  • triamterene

    candesartan and triamterene both increase serum potassium. Modify Therapy/Monitor Closely.

  • trimethoprim

    trimethoprim and candesartan both increase serum potassium. Use Caution/Monitor. Trimethoprim decreases urinary potassium excretion. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia.

  • voclosporin

    voclosporin and candesartan both increase serum potassium. Use Caution/Monitor.voclosporin, candesartan.Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.

  • xipamide

    xipamide increases effects of candesartan by pharmacodynamic synergism. Use Caution/Monitor.

  • Atacand (candesartan) dosing, indications, interactions, adverse effects, and more (2024)

    FAQs

    What is the difference between Atacand and candesartan? ›

    Candesartan is a prescription drug. It comes as an oral tablet. Candesartan is available as the brand-name drug Atacand.

    What should be avoided when taking candesartan? ›

    Do not use salt substitutes such as Lo-Salt. This is because they are high in potassium. When mixed with candesartan they may make the level of potassium in your blood too high. Eating a healthy, balanced diet can help if you have high blood pressure or heart failure.

    Who should not take atacand? ›

    Decreased Blood Pressure (Hypotension).

    Candesartan may cause low blood pressure, especially in people with low levels of fluids or salt. This can happen especially in people taking a medicine that causes you to pee more often (diuretic).

    What are the most common side effects of candesartan? ›

    Side Effects
    • Arm, back, or jaw pain.
    • bleeding gums.
    • chest pain or discomfort.
    • chest tightness or heaviness.
    • cough or hoarseness.
    • fainting.
    • fast or irregular heartbeat.
    • joint pain.
    Feb 1, 2024

    Can you eat bananas when taking candesartan? ›

    Interactions of Candesartan

    This medicine has interactions with food rich in potassium (spinach, banana, green leafy vegetables, peas) and foods containing high amount of fat. One must avoid such foods while taking this medicine...

    What is the best blood pressure medication with the least side effects? ›

    Which High Blood Pressure Medications Have the Least Side Effects? One large study suggested that thiazide water pills (diuretics) have fewer side effects and work better on average than other drugs commonly prescribed as first treatments for high blood pressure.

    Can I take vitamin D with candesartan? ›

    Interactions between your drugs

    No interactions were found between candesartan and Vitamin D3.

    Does candesartan affect your eyes? ›

    This drug can cause certain eye problems. If left untreated, this can lead to lasting eyesight loss. If eye problems happen, signs like change in eyesight or eye pain most often happen within hours to weeks of starting this drug. Call your doctor right away if you have these signs.

    Does candesartan affect sleep? ›

    The following side effects have been reported very rarely by patients taking CANDESARTAN HCTZ AN: palpitations, agitation, anxiety, depression, trouble sleeping (insomnia), drowsiness (somnolence), nervousness, nightmare and sleep disorder.

    What are the two worst blood pressure medications? ›

    5 of the worst blood pressure medications
    1. Beta blockers. Usually, beta blockers aren't used as first-choice therapies to lower blood pressure. ...
    2. Loop diuretics. Furosemide (Lasix) is a type of diuretic (water pill) known as a loop diuretic. ...
    3. Alpha blockers. ...
    4. Vasodilators. ...
    5. Alpha-2 agonists.

    Can you eat bananas on blood pressure medication? ›

    ACE inhibitors, such as captopril, enalapril, lisinopril, perindopril, and ramipril are designed to lower blood pressure, so if you take them while eating a lot of bananas you could inadvertently send your potassium levels through the roof which can lead to an irregular heart-beat.

    Is 8 mg of candesartan a lot? ›

    For adults, the usual dose is: high blood pressure – 8mg to 32mg once a day. heart failure – 4mg to 32mg once a day.

    What painkillers can you take with candesartan? ›

    Candesartan may not always be safely taken with non-steroidal anti-inflammatory drugs, which are painkillers like aspirin and ibuprofen. When taken together, this can affect the kidneys. Speak to your doctor if you take these medications. You can take other painkillers, such as paracetamol.

    Is losartan safer than candesartan? ›

    There is no difference in their safety/tolerability profile. This study confirms that candesartan cilexetil is a more effective antihypertensive agent than losartan when compared at once‐daily maximum doses.

    Why is candesartan so expensive? ›

    "The differences are large, but the result is complicated by the fact that candesartan is a patented substance and relatively expensive, while losartan is now patent-free and cheaper", says Dr Lars Lund at the Department of Medicine, Solna, who led the study.

    Why is candesartan preferred? ›

    Candesartan may be preferred over losartan due to its minimal metabolism requirements and its potential for use in patients with mild hepatic dysfunction.

    What is the first drug of choice for hypertension? ›

    There are multiple classes of antihypertensive medications used for the treatment of HTN; the most recommended classes used as first-line for treatment are: Thiazide-type diuretics. Calcium channel blockers. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs)

    What is the next name for candesartan? ›

    Names. The prodrug candesartan cilexetil is marketed by AstraZeneca and Takeda Pharmaceuticals, commonly under the trade names Blopress, Atacand, Amias, and Ratacand. It is available in generic form.

    Is Atacand a good blood pressure medication? ›

    It's one of the first-choice medication for treating high blood pressure in adults and children. It can also help lower the risk of worsening heart failure in adults.

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